Validating the Accuracy of Novel, Non-contrast, Cardiac Magnetic resOnaNce Imaging in Defining Myocardial FIbRosis in Patients With End-stage Renal Disease on haeModialysis: the CONFIRM Study
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Procedure
Study Type: Observational
SUMMARY
There are currently no good ways of measuring levels of scarring in the hearts of patients with advanced kidney disease and patients on dialysis, although recent research has shown a new cardiac MRI technique, called native T1 mapping, may provide a solution to this. To assess the accuracy of this novel technique in dialysis patients, it is essential to undertake a study which compares native T1 mapping to actual levels of scarring in the hearts of patients on dialysis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
View:
• Prevalent haemodialysis patient (more than 3 months)
• Active on the supportive care register with anticipated death in the subsequent 12 months
• Able to give informed consent
• Consent to donation of heart for research following death
• Able to understand written and verbal explanations in English
Locations
Other Locations
United Kingdom
University Hospitals of Leicester NHS Trust
RECRUITING
Leicester
Contact Information
Primary
James Burton, DM, FRCP
jb343@le.ac.uk
+44 (0)116 2588043
Backup
Matthew Graham-Brown, MBChB, MRCP
mgb23@le.ac.uk
+44 (0)116 2588043
Time Frame
Start Date:2019-11-03
Estimated Completion Date:2025-12-31
Participants
Target number of participants:9
Treatments
Haemodialysis patients
The plans for patient recruitment were developed in partnership with our local haemodialysis patient participation and involvement group. Patients will be identified from the supportive care register established for haemodialysis patients in Leicester in 2008.~Inclusion:~* Prevalent haemodialysis patient (more than 3 months)~* Active on the supportive care register with anticipated death in the subsequent 12 months~* Able to give informed consent~* Consent to donation of heart for research following death~* Able to understand written and verbal explanations in English~Exclusion:~* Contraindication to MRI scan (e.g. pacemaker, incompatible metallic implants, claustrophobia)~* Patients with expected or potential infiltrative cardiomyopathy (e.g. amyloidosis)~* Unable to give informed consent~* Unable to understand written and verbal explanations in English